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Nat Rev Cancer. 2013 Dec;13(12):871-82. doi: 10.1038/nrc3627.

VEGF targets the tumour cell.

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1
Department of Cancer Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA.

Abstract

The function of vascular endothelial growth factor (VEGF) in cancer is not limited to angiogenesis and vascular permeability. VEGF-mediated signalling occurs in tumour cells, and this signalling contributes to key aspects of tumorigenesis, including the function of cancer stem cells and tumour initiation. In addition to VEGF receptor tyrosine kinases, the neuropilins are crucial for mediating the effects of VEGF on tumour cells, primarily because of their ability to regulate the function and the trafficking of growth factor receptors and integrins. This has important implications for our understanding of tumour biology and for the development of more effective therapeutic approaches.

PMID:
24263190
PMCID:
PMC4011842
DOI:
10.1038/nrc3627
[Indexed for MEDLINE]
Free PMC Article
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