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Pancreas. 2014 Jan;43(1):135-40. doi: 10.1097/MPA.0b013e3182a8d41f.

High-dose aspirin consumption contributes to decreased risk for pancreatic cancer in a systematic review and meta-analysis.

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  • 1From the *Department of General Surgery, Wendeng Central Hospital, Wei Hai City; †Department of General Surgery, Linyi People's Hospital, Lin Yi City, Shan Dong Province; ‡Department of Oncology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou; and §Department of Gynaecology and Obstetrics, the First Affiliated Hospital of Xinxiang Medical College, Xinxiang, China.



The aim of this study was to analyze the association between aspirin intake and its effect for chemoprevention of pancreatic cancer incidence by using a meta-analysis method.


The databases of MEDLINE, EMBASE, and Wangfang (Chinese database) were retrieved to identify eligible studies. Odds ratio (OR) and 95% confidence interval (CI) were calculated using a random-effects model.


A total of 10 studies (4 case-control studies, 5 prospective cohort studies, and 1 randomized controlled trial) with 7,252 cases of pancreatic cancer and more than 120,0000 healthy control subjects were enrolled in the studies. Pooled analyses showed that high-dose aspirin intake was marginally associated with decreased risk for pancreatic cancer for overall analysis (OR, 0.88; 95% CI, 0.76-1.01) as well as for both cohort and case-control studies (OR, 0.70; 95% CI, 0.54-1.16, for the cohort studies; OR, 0.82; 95% CI, 0.62-1.02, for the case-control studies), without between-study heterogeneity. Stratified analysis for Americans showed a similar result (OR, 0.82; 95% CI, 0.65-1.02). In contrast, our study inferred that low-dose aspirin intake was not associated with risk for pancreatic cancer for the total and subgroup analyses.


In summary, our study indicated that high-dose aspirin, rather than low-dose aspirin, might be associated with decreased risk for pancreatic cancer, especially for Americans.

[PubMed - indexed for MEDLINE]
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