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J Child Neurol. 2014 Dec;29(12):NP176-80. doi: 10.1177/0883073813509888. Epub 2013 Nov 21.

Continuous spike and wave in slow-wave sleep in a patient with Rett syndrome and in a patient with Lhermitte-Duclos syndrome and neurofibromatosis 1.

Author information

1
NJ Neuroscience Institute at JFK Medical Center/Seton Hall University, Edison, NJ, USA sbhat2012@yahoo.com.
2
NJ Neuroscience Institute at JFK Medical Center/Seton Hall University, Edison, NJ, USA Department of Neurology and Neurosciences, New Jersey Medical School UMDNJ Newark, Newark, NJ, USA.
3
NJ Neuroscience Institute at JFK Medical Center/Seton Hall University, Edison, NJ, USA.

Abstract

Continuous spike and wave in slow-wave sleep (CSWS) is an electroencephalographic (EEG) pattern characterized by generalized spike-wave discharges occurring for at least 85% of non-rapid eye movement (non-REM) sleep, with marked attenuation during rapid eye movement (REM) sleep. It has been described in a large number of structural and nonstructural neurologic conditions and is associated with epilepsy, behavioral disturbances, and severe neuropsychiatric impairment. We describe continuous spike and wave in slow-wave sleep in 2 patients (one with Rett syndrome and the other with Lhermitte-Duclos syndrome). To our knowledge, continuous spike and wave in slow-wave sleep has not been previously described in these conditions.

KEYWORDS:

CSWS; Cowden disease; Lhermitte-Duclos syndrome; Rett syndrome; continuous spike and wave in slow-wave sleep

PMID:
24262385
DOI:
10.1177/0883073813509888
[Indexed for MEDLINE]
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