Format

Send to

Choose Destination
See comment in PubMed Commons below
Ultrasound Med Biol. 2014 Feb;40(2):410-21. doi: 10.1016/j.ultrasmedbio.2013.09.018. Epub 2013 Nov 19.

Broadband attenuation measurements of phospholipid-shelled ultrasound contrast agents.

Author information

  • 1Biomedical Engineering Program, University of Cincinnati, Cincinnati, Ohio, USA. Electronic address: raymonjl@mail.uc.edu.
  • 2Biomedical Engineering Program, University of Cincinnati, Cincinnati, Ohio, USA; Division of Cardiovascular Diseases, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
  • 3Division of Cardiovascular Diseases, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
  • 4Biomedical Engineering Program, University of Cincinnati, Cincinnati, Ohio, USA.
  • 5Division of Cardiology, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA.

Abstract

The aim of this study was to characterize the frequency-dependent acoustic attenuation of three phospholipid-shelled ultrasound contrast agents (UCAs): Definity, MicroMarker and echogenic liposomes. A broadband through-transmission technique allowed for measurement over 2 to 25 MHz with a single pair of transducers. Viscoelastic shell parameters of the UCAs were estimated using a linearized model developed by N. de Jong, L. Hoff, T. Skotland and N. Bom (Ultrasonics 1992; 30:95-103). The effect of diluent on the attenuation of these UCA suspensions was evaluated by performing attenuation measurements in 0.5% (w/v) bovine serum albumin and whole blood. Changes in attenuation and shell parameters of the UCAs were investigated at room temperature (25°C) and physiologic temperature (37°C). The attenuation of the UCAs diluted in 0.5% (w/v) bovine serum albumin was found to be identical to the attenuation of UCAs in whole blood. For each UCA, attenuation was higher at 37°C than at 25°C, underscoring the importance of conducting characterization studies at physiologic temperature. Echogenic liposomes exhibited a larger increase in attenuation at 37°C versus 25°C than either Definity or MicroMarker.

KEYWORDS:

Broadband characterization; Definity; Echogenic liposomes; MicroMarker; Microbubbles; Polyvinylidene fluoride transducer; Size distribution; Ultrasound contrast agents

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center