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J Phys Ther Sci. 2013 Oct;25(10):1317-9. doi: 10.1589/jpts.25.1317. Epub 2013 Nov 20.

Effects of endurance exercise on mitochondrial function in mice.

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1
Department of Sports and Leisure Studies, College of Humanity, Daegu University, Republic of Korea.

Abstract

[Purpose] The purpose of this study was to investigate the effects of 8 weeks of endurance exercise on the cardiac mitochondrial function of mice. [Subjects] Ten 129 SvJ/C57BL6 Male mice were used. The mice were randomly divided into an exercise group (n=5; mean ± SD weight, 27.4 ± 1.6 g) and a control (n=5; mean ± SD weight, 28.2 ± 1.1 g). The exercise mice ran on a motor driven treadmill 5 days per week for 30 minutes at a speed of 24 m/min for 8 weeks. Mitochondrial function as measured RCI was compared between the exercise and control group mice using an independent t test. [Results] The exercise mice had a significantly greater state 4 respiration than to the sedentary control mice. There was also a significant difference in RCI between exercise and sedentary control mice. [Conclusion] Endurance exercise decreased RCI, indicating an uncoupling of respiration and oxidative phosphorylation.

KEYWORDS:

Cardiac hypertrophy; Endurance exercise; Treadmill

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