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Adv Biochem Eng Biotechnol. 2014;139:1-9. doi: 10.1007/10_2013_255.

Mammalian cell cultures for biologics manufacturing.

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Upstream Development, Alexion Pharmaceuticals, Cheshire, CT, 06410, USA,


Biopharmaceuticals represent a growing sector of the pharmaceutical industry, and are used for a wide range of indications, including oncology and rheumatology. Cultured mammalian cells have become the predominant expression system for their production, partly due to their ability to complete the posttranslational modifications required for drug safety and efficacy. Over the past decade, the productivity of mammalian cell culture production processes has growth dramatically through improvements in both volumetric and specific productivities. This article presents an overview of the biologics market, including analysis of sales and approvals; as well as a review of industrial production cell lines and cell culture operations.

[Indexed for MEDLINE]

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