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Neurochem Res. 2014 Jan;39(1):1-36. doi: 10.1007/s11064-013-1199-5. Epub 2013 Nov 21.

A guide to the metabolic pathways and function of metabolites observed in human brain 1H magnetic resonance spectra.

Author information

1
Neuroscience Research Australia, Barker St, Randwick, NSW, 2031, Australia, c.rae@unsw.edu.au.

Abstract

The current knowledge of the normal biochemistry of compounds that give rise to resonances in human brain proton magnetic resonance spectra measureable at readily available field strengths (i.e. ≤3 T) is reviewed. Molecules covered include myo- and scyllo-inositol, glycerophospho- and phospho-choline and choline, creatine and phosphocreatine, N-acetylaspartate, N-acetylaspartylglutamate, glutamate, glutamine, γ-aminobutyrate, glucose, glutathione and lactate. The factors which influence changes in the levels of these compounds are discussed. As most proton resonances in the brain at low field are derived from a combination of moieties whose biochemistry is complex and interrelated, an understanding of the mechanisms underlying why these species change is crucial to meaningful interpretation of human brain spectra.

PMID:
24258018
DOI:
10.1007/s11064-013-1199-5
[Indexed for MEDLINE]

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