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J Int Assoc Provid AIDS Care. 2014 Mar-Apr;13(2):113-6. doi: 10.1177/2325957413508320. Epub 2013 Nov 20.

Sickle cell disease and HIV: a case highlighting management challenges for children in a resource-limited setting.

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Academic Model Providing Access to Healthcare (AMPATH), Eldoret, Kenya.


Sickle cell disease (SCD) is a genetic disorder resulting from a mutation in the hemoglobin (Hb) gene. Sickle cell disease results in chronic anemia and a variety of acute and chronic complications that can lead to early mortality. A child with both SCD and HIV presents a management challenge, particularly in a resource-limited setting. In this case report, we describe the case of an 18-month-old Kenyan girl with SCD and HIV who developed a severe hypersensitivity reaction to first-line antiretroviral therapy (ART). Selecting an appropriate drug substitute for a child with SCD and HIV presents a management dilemma when the available options have problematic side effect profiles or are inaccessible or inappropriate according to national guidelines. The challenges in choosing an appropriate ART regimen for a child with SCD and HIV highlight the lack of data and scarcity of treatment options for pediatric patients.


HIV; antiretroviral therapy; comorbidity; sickle cell disease

[Indexed for MEDLINE]

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