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Int J Mol Sci. 2013 Nov 19;14(11):22817-25. doi: 10.3390/ijms141122817.

Usefulness of plasma YKL-40 in management of community-acquired pneumonia severity in patients.

Author information

1
Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan. cshy046@csh.org.tw.

Abstract

Plasma YKL-40 level has been reported as playing a significant role in community-acquired pneumonia (CAP). However, the correlation between plasma level of YKL-40 and the severity of CAP has not been reported. This study identifies the relationship between plasma level changes of the YKL-40 gene in adult patients hospitalized with CAP. The ELISA was used to measure the plasma YKL-40 level from 61 adult CAP patients before and after antibiotic treatment and from 60 healthy controls. The plasma YKL-40 levels were significantly increased in patients with CAP compared to normal controls. Moreover, the plasma concentration of YKL-40 correlated with the severity of CAP based on the pneumonia severity index (PSI) score (r = 0.630, p < 0.001), the CURB-65 (confusion, uremia, respiratory rate, BP, age 65 years) score (r = 0.640, p < 0.001), the Acute Physiology And Chronic Health Evaluation II (APACHE II) score (r = 0.539, p < 0.001) and length of hospital stay (r = 0.321, p = 0.011), respectively. In conclusion, plasma YKL-40 may play a role in the diagnosis and clinical assessment of CAP severity, which could potentially guide the development of treatment strategies.

PMID:
24256818
PMCID:
PMC3856092
DOI:
10.3390/ijms141122817
[Indexed for MEDLINE]
Free PMC Article

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