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Phytochemistry. 2014 Jan;97:88-95. doi: 10.1016/j.phytochem.2013.10.011. Epub 2013 Nov 17.

Diterpenoid alkaloids and flavonoids from Delphinium trichophorum.

Author information

1
Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou 510405, PR China.
2
School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China.
3
Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou 510405, PR China. Electronic address: zhuchenchen@vip.sina.com.
4
Tibetan Traditional Medical College, Lasa 850000, PR China.

Abstract

Five hetisane-type C20-diterpenoid alkaloids, trichodelphinines A-E, one delnudine-type C20-diterpenoid alkaloid, trichodelphinine F and three known flavonoids, quercetin, quercetin 3-O-β-D-glucopyranoside, and quercetin 3-O-β-D-glucopyranoside-7-O-α-L-arabinopyranoside, were isolated from whole plants of Delphinium trichophorum Franch. Their structures were elucidated on the basis of extensive spectroscopic analysis, including HSQC, HMBC, (1)H-(1)H COSY, NOESY and X-ray crystallographic analysis, and from chemical evidence. The cytotoxic activities of the diterpenoid alkaloids were evaluated using the MTT method, and the IC50 values of their cytotoxicity against A549 cancer cells ranged from 12.03 to 52.79 μM.

KEYWORDS:

Delnudine-type diterpenoid alkaloid; Delphinium trichophorum Franch; Diterpenoid alkaloid; Hetisane-type diterpenoid alkaloid; KRXFYFOHIOSSNE-ZXMOXNTFSA-N; Ranunculaceae; ULBJMFAWRDNRAM-JCTIUFQSSA-N; VPGOXBOVBANQMB-OQWYUALGSA-N; WDOZPTBXHDZRAC-GJGFCZQESA-N; WNZAQACNVGQHRH-NRNHFJSPSA-N; YPJJUKPGIAXPIU-RAXXLDHPSA-N

PMID:
24256579
DOI:
10.1016/j.phytochem.2013.10.011
[Indexed for MEDLINE]

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