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Org Lett. 2013 Dec 6;15(23):6018-21. doi: 10.1021/ol402908m. Epub 2013 Nov 20.

Intramolecular dehydrative coupling of tertiary amines and ketones promoted by KO-t-Bu/DMF: a new synthesis of indole derivatives.

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1
Institute of Drug Synthesis and Pharmaceutical Process, School of Pharmaceutical Sciences, Sun Yat-sen University , Guangzhou 510006, China.

Abstract

A new synthesis of indole derivatives has been achieved through intramolecular dehydrative coupling of tertiary amines and ketones promoted by KO-t-Bu/DMF. The reaction probably proceeds via an α-amino alkyl radical pathway.

PMID:
24256568
DOI:
10.1021/ol402908m
[Indexed for MEDLINE]
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