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Biochem Soc Trans. 2013 Dec;41(6):1750-4. doi: 10.1042/BST20130208.

Formin-based control of the actin cytoskeleton during cytokinesis.

Author information

1
*Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, U.S.A.

Abstract

Cytokinesis, the terminal event in the canonical cell cycle, physically separates daughter cells following mitosis. For cleavage to occur in many eukaryotes, a cytokinetic ring must assemble and constrict between divided genomes. Although dozens of different molecules localize to and participate within the cytokinetic ring, the core machinery comprises linear actin filaments. Accordingly, formins, which nucleate and elongate F-actin (filamentous actin) for the cytokinetic ring, are required for cytokinesis in diverse species. In the present article, we discuss specific modes of formin-based actin regulation during cell division and highlight emerging mechanisms and questions on this topic.

PMID:
24256286
PMCID:
PMC5563852
DOI:
10.1042/BST20130208
[Indexed for MEDLINE]
Free PMC Article

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