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Biochem Soc Trans. 2013 Dec;41(6):1687-91. doi: 10.1042/BST20130210.

GCN2, an old dog with new tricks.

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*Department of Cell Biology, Institute for Cancer Research, Montebello, 0310 Oslo, Norway.


Gcn2 was first described in budding yeast as a serine/threonine protein kinase involved in the response to amino acid starvation and this is its best characterized role to date. Recent work has revealed new and exciting roles for Gcn2, which affect many aspects of cellular physiology in response to a number of stresses in addition to starvation. Furthermore, the Gcn2 pathway has been implicated in diseases such as cancer and Alzheimer's disease, and therefore elucidating the new roles of Gcn2 seems ever more important.

[Indexed for MEDLINE]

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