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Org Lett. 2013 Dec 6;15(23):6106-9. doi: 10.1021/ol4029995. Epub 2013 Nov 20.

Xylogranin B: a potent Wnt signal inhibitory limonoid from Xylocarpus granatum.

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1
Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan , Pharmacy Discipline, Life Science School, Khulna University , Khulna 9208, Bangladesh , and Department of Pharmaceutical Chemistry, University of Dhaka , Dhaka 1000, Bangladesh.

Abstract

Xylogranin B (2) was isolated from Xylocarpus granatum (Meliaceae) leaves, by use of a cell-based luciferase screening system targeting a Wnt signaling pathway. Compound 2 inhibited TCF/β-catenin transcriptional activity (IC50 48.9 nM) and exhibited strong cytotoxicity against colon cancer cell lines. Compound 2 significantly decreased β-catenin protein levels in nuclei but not in the cytosol. These results indicated that a decrease in β-catenin levels in nuclei by 2 resulted in the Wnt signal inhibitory effects of 2.

PMID:
24255943
DOI:
10.1021/ol4029995
[Indexed for MEDLINE]
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