Format

Send to

Choose Destination
Development. 2013 Dec;140(23):4647-56. doi: 10.1242/dev.079087.

Nutritional regulation of stem and progenitor cells in Drosophila.

Author information

1
Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA.

Abstract

Stem cells and their progenitors are maintained within a microenvironment, termed the niche, through local cell-cell communication. Systemic signals originating outside the niche also affect stem cell and progenitor behavior. This review summarizes studies that pertain to nutritional effects on stem and progenitor cell maintenance and proliferation in Drosophila. Multiple tissue types are discussed that utilize the insulin-related signaling pathway to convey nutritional information either directly to these progenitors or via other cell types within the niche. The concept of systemic control of these cell types is not limited to Drosophila and may be functional in vertebrate systems, including mammals.

KEYWORDS:

Amino acid sensing; Dilp; Drosophila; Germline stem cell; Hematopoietic progenitor cell; Insulin; Intestinal stem cell; Neural stem cell; Nutritional control

PMID:
24255094
PMCID:
PMC3833425
DOI:
10.1242/dev.079087
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center