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Nucleic Acids Res. 2014 Jan;42(Database issue):D517-20. doi: 10.1093/nar/gkt1153. Epub 2013 Nov 18.

MultitaskProtDB: a database of multitasking proteins.

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Departament de Bioquímica i Biologia Molecular, Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Bellaterra, Barcelona 08193, Spain,Laboratorio de Inmunología, Universidad de la República Regional Norte-Salto, Rivera 1350, Salto 50000, Uruguay and Departament de Medicina Experimental, Institut de Recerca Biomèdica, Universitat de Lleida, Lleida 25198, Spain.


We have compiled MultitaskProtDB, available online at, to provide a repository where the many multitasking proteins found in the literature can be stored. Multitasking or moonlighting is the capability of some proteins to execute two or more biological functions. Usually, multitasking proteins are experimentally revealed by serendipity. This ability of proteins to perform multitasking functions helps us to understand one of the ways used by cells to perform many complex functions with a limited number of genes. Even so, the study of this phenomenon is complex because, among other things, there is no database of moonlighting proteins. The existence of such a tool facilitates the collection and dissemination of these important data. This work reports the database, MultitaskProtDB, which is designed as a friendly user web page containing >288 multitasking proteins with their NCBI and UniProt accession numbers, canonical and additional biological functions, monomeric/oligomeric states, PDB codes when available and bibliographic references. This database also serves to gain insight into some characteristics of multitasking proteins such as frequencies of the different pairs of functions, phylogenetic conservation and so forth.

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