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J Gastroenterol Hepatol. 2013 Dec;28 Suppl 4:29-32. doi: 10.1111/jgh.12270.

Trans fatty acids in diets act as a precipitating factor for gut inflammation?

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Department of Internal Medicine, National Defense Medical College, Tokorozawa City, Saitama, Japan.


Fatty acids in our daily diet are broadly classified into cis and trans fatty acids (TFAs). TFAs are formed during the manufacturing process of hydrogenated vegetable oils such as margarine. Modern diets such as deep-fried products, frozen foods, and packaged snacks commonly include large quantities of margarine containing TFAs. Although an increased report in the effects of the diet containing TFAs on a risk factor of metabolic syndrome, diabetes mellitus, and coronary heart disease has been observed in the recent years, influence on intestinal inflammation remains unknown. This review describes pro-inflammatory effects of TFAs in our diary diet on various systemic disorders and also discusses a possible role of TFAs on gut inflammation.


gut inflammation; macrophages; pro-inflammatory cytokines; trans-fatty acids

[Indexed for MEDLINE]

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