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J Pharmacol Pharmacother. 2013 Oct;4(4):303-6. doi: 10.4103/0976-500X.119726.

How to calculate sample size in animal studies?

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Department of Pharmacology, GMERS Medical College, Patan, Government Medical College, Surat, Gujarat, India.


Calculation of sample size is one of the important component of design of any research including animal studies. If a researcher select less number of animals it may lead to missing of any significant difference even if it exist in population and if more number of animals selected then it may lead to unnecessary wastage of resources and may lead to ethical issues. In this article, on the basis of review of literature done by us we suggested few methods of sample size calculations for animal studies.


Alpha error; animal studies; power; sample size

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