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J Leukoc Biol. 2014 Feb;95(2):243-50. doi: 10.1189/jlb.0513307. Epub 2013 Nov 18.

Bruton's tyrosine kinase--an integral protein of B cell development that also has an essential role in the innate immune system.

Author information

1
1.Col. Insurgentes Cuicuilco, Torre de Investigación 9o. piso, Mexico, D.F., Mexico 04530. glopezh@pediatria.gob.mx.

Abstract

Btk is the protein affected in XLA, a disease identified as a B cell differentiation defect. Btk is crucial for B cell differentiation and activation, but its role in other cells is not fully understood. This review focuses on the function of Btk in monocytes, neutrophils, and platelets and the receptors and signaling cascades in such cells with which Btk is associated.

KEYWORDS:

TLRs; XLA; inflammation

PMID:
24249742
DOI:
10.1189/jlb.0513307
[Indexed for MEDLINE]

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