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Protein Cell. 2013 Dec;4(12):904-10. doi: 10.1007/s13238-013-3084-z. Epub 2013 Nov 18.

Mutual regulation between Hippo signaling and actin cytoskeleton.

Author information

1
Intercollege Graduate Degree Program in Cell and Developmental Biology, The Pennsylvania State University, University Park, PA, 16802, USA.

Abstract

Hippo signaling plays a crucial role in growth control and tumor suppression by regulating cell proliferation, apoptosis, and differentiation. How Hippo signaling is regulated has been under extensive investigation. Over the past three years, an increasing amount of data have supported a model of actin cytoskeleton blocking Hippo signaling activity to allow nuclear accumulation of a downstream effector, Yki/Yap/Taz. On the other hand, Hippo signaling negatively regulates actin cytoskeleton organization. This review provides insight on the mutual regulatory mechanisms between Hippo signaling and actin cytoskeleton for a tight control of cell behaviors during animal development, and points out outstanding questions for further investigations.

PMID:
24248471
PMCID:
PMC4875399
DOI:
10.1007/s13238-013-3084-z
[Indexed for MEDLINE]
Free PMC Article

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