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Leukemia. 2014 Mar;28(3):518-24. doi: 10.1038/leu.2013.344. Epub 2013 Nov 19.

Inherited genetic susceptibility to multiple myeloma.

Author information

1
Haemato-Oncology Research Unit, Division of Molecular Pathology, Institute of Cancer Research, Surrey, UK.
2
Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
3
Multiple Myeloma Section, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
4
Department of Preventive Medicine, Creighton's Hereditary Cancer Center, Omaha, NE, USA.
5
1] Division of Molecular Genetic Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany [2] Center for Primary Health Care Research, Lund University, Malmö, Sweden.
6
Division of Genetics and Epidemiology, Institute of Cancer Research, Surrey, UK.

Abstract

Although the familial clustering of multiple myeloma (MM) supports the role of inherited susceptibility, only recently has direct evidence for genetic predisposition been demonstrated. A meta-analysis of two genome-wide association (GWA) studies has identified single-nucleotide polymorphisms (SNPs) localising to a number of genomic regions that are robustly associated with MM risk. In this review, we provide an overview of the evidence supporting a genetic contribution to the predisposition to MM and MGUS (monoclonal gammopathy of unknown significance), and the insight this gives into the biological basis of disease aetiology. We also highlight the promise of future approaches to identify further specific risk factors and their potential clinical utility.

PMID:
24247655
DOI:
10.1038/leu.2013.344
[Indexed for MEDLINE]

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