Format

Send to

Choose Destination
See comment in PubMed Commons below
Lab Invest. 2014 Jan;94(1):31-40. doi: 10.1038/labinvest.2013.132. Epub 2013 Nov 18.

Matrikine and matricellular regulators of EGF receptor signaling on cancer cell migration and invasion.

Author information

1
Department of Pathology, University of Pittsburgh, Pittsburgh VAMC, Pittsburgh, PA, USA.

Abstract

Cancer invasion is a complex process requiring, among other events, extensive remodeling of the extracellular matrix including deposition of pro-migratory and pro-proliferative moieties. In recent years, it has been described that while invading through matrices cancer cells can change shape and adapt their migration strategies depending on the microenvironmental context. Although intracellular signaling pathways governing the mesenchymal to amoeboid migration shift and vice versa have been mostly elucidated, the extracellular signals promoting these shifts are largely unknown. In this review, we summarize findings that point to matrikines that bind specifically to the EGF receptor as matricellular molecules that enable cancer cell migrational plasticity and promote invasion.

PMID:
24247562
PMCID:
PMC4038324
DOI:
10.1038/labinvest.2013.132
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Support Center