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Dig Dis. 2013;31(3-4):388-90. doi: 10.1159/000354707. Epub 2013 Nov 14.

Lecithin as a therapeutic agent in ulcerative colitis.

Author information

1
Department of Gastroenterology, Internal Medicine IV, University Clinics of Heidelberg, Heidelberg, Germany.

Abstract

Lecithin [phosphatidylcholine (PC)] was shown to account for more than 70% of total phospholipids within the intestinal mucus layer. It is arranged in lamellar membranes (surfactant-like particles) and establishes a hydrophobic barrier preventing invasion of the colonic commensal microbiota. In ulcerative colitis (UC), the mucus PC content was demonstrated to be reduced by about 70%, irrespective of the presence of inflammation. This may be of primary pathogenetic significance allowing bacteria to enter the mucus and induce mucosal inflammation. Therefore, a new therapeutic strategy is being developed to substitute the missing mucus PC content in UC. Indeed, a delayed-release PC formulation was able to compensate the lack of PC and improve the inflammatory activity. In randomized controlled studies, delayed-release PC was proven to be clinically and endoscopically effective, which now awaits a phase III authority approval trial.

PMID:
24246994
DOI:
10.1159/000354707
[Indexed for MEDLINE]

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