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Mitochondrion. 2014 Jan;14(1):42-8. doi: 10.1016/j.mito.2013.11.001. Epub 2013 Nov 15.

Effect of near-infrared light exposure on mitochondrial signaling in C2C12 muscle cells.

Author information

1
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, United States.
2
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, United States. Electronic address: padhihetty@hhp.ufl.edu.

Abstract

Near-infrared (NIR) light is a complementary therapy used to treat musculoskeletal injuries but the underlying mechanisms are unclear. Acute NIR light treatment (~800-950 nm; 22.8 J/cm(2)) induced a dose-dependent increase in mitochondrial signaling (AMPK, p38 MAPK) in differentiated muscle cells. Repeated NIR light exposure (4 days) appeared to elevate oxidative stress and increase the upstream mitochondrial regulatory proteins AMPK (3.1-fold), p38 (2.8-fold), PGC-1α (19.7%), Sirt1 (26.8%), and reduced RIP140 (23.2%), but downstream mitochondrial regulation/content (Tfam, NRF-1, Sirt3, cytochrome c, ETC subunits) was unaltered. Our data indicates that NIR light alters mitochondrial biogenesis signaling and may represent a mechanistic link to the clinical benefits.

KEYWORDS:

Mitochondrial biogenesis; NIR light; Oxidative stress; Photobiomodulation; Reactive oxygen species

PMID:
24246911
DOI:
10.1016/j.mito.2013.11.001
[Indexed for MEDLINE]

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