Format

Send to

Choose Destination
See comment in PubMed Commons below
J Oral Maxillofac Surg. 2014 Apr;72(4):724-9. doi: 10.1016/j.joms.2013.09.013. Epub 2013 Nov 15.

Epstein-Barr virus-positive oral ulceration simulating Hodgkin lymphoma in a patient treated with methotrexate: case report and review of the literature.

Author information

1
Assistant Professor, Department of Diagnostic Sciences, Texas A&M University Baylor College of Dentistry, Dallas, TX. Electronic address: anaidu@bcd.tamhsc.edu.
2
Professor, Department of Diagnostic Sciences, Texas A&M University Baylor College of Dentistry, Dallas, TX.
3
Clinical Professor, Department of Oral and Maxillofacial Surgery, Texas A&M University Baylor College of Dentistry, Dallas, TX.

Abstract

Immunosuppressive therapy for patients diagnosed with rheumatoid arthritis has long been implicated in the development of various neoplastic processes, including leukemia and lymphoma. Methotrexate is a commonly administered antimetabolic medication thought to improve the symptoms of rheumatoid arthritis through its anti-inflammatory effects. Longterm methotrexate therapy and concurrent rheumatoid arthritis have both been independently suggested as risk factors for developing lymphoma. The mechanism has been theorized to be severe immunosuppression and an increased frequency of latent infection with pro-oncogenic viruses, such as the Epstein-Barr virus (EBV). Spontaneous remission of these malignancies has been seen after discontinuation of the methotrexate therapy. In the present study, we report the case of a patient diagnosed with rheumatoid arthritis and treated with methotrexate and prednisone. She developed intraoral ulcerations that histopathologically resembled Hodgkin's lymphoma.

PMID:
24246254
DOI:
10.1016/j.joms.2013.09.013
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center