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Ann Rheum Dis. 2015 Jan;74(1):177-84. doi: 10.1136/annrheumdis-2013-203927. Epub 2013 Nov 15.

Damage in the anca-associated vasculitides: long-term data from the European vasculitis study group (EUVAS) therapeutic trials.

Author information

1
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science (NDORMs), University of Oxford, Oxford, USA Rheumatology Department, Nuffield Orthopaedic Centre, Oxford, UK.
2
Department of Population Health, Norwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, UK.
3
Department of Rheumatology, Auckland District Health Board, Auckland, New Zealand.
4
Renal Department, Royal Berkshire NHS Foundation Trust, Reading, UK.
5
School of Immunity and Infection, Centre for Translational Inflammation Research, University of Birmingham, Birmingham, UK.
6
Competence Centre for Clinical Research, Skane University Hospital, Lund, Sweden.
7
Renal Department, Addenbrooke's Hospital, Cambridge, UK.
8
Department of Internal Medicine, Hospital Saint-Louis, Paris, France.
9
Nephrology and Transplantation, Skane University Hospital Malmo, Lund University, Malmo, Sweden.
10
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science (NDORMs), University of Oxford, Oxford, USA.

Abstract

OBJECTIVES:

To describe short-term (up to 12 months) and long-term (up to 7 years) damage in patients with newly diagnosed antineutrophil-cytoplasm antibody-associated vasculitis (AAV).

METHODS:

Data were combined from six European Vasculitis Study group trials (n=735). Long-term follow-up (LTFU) data available for patients from four trials (n=535). Damage accrued was quantified by the Vasculitis Damage Index (VDI). Sixteen damage items were defined a priori as being potentially treatment-related.

RESULTS:

VDI data were available for 629 of 735 patients (85.6%) at baseline, at which time 217/629 (34.5%) had ≥1 item of damage and 32 (5.1%) ≥5 items, reflecting disease manifestations prior to diagnosis and trial enrolment. LTFU data were available for 467/535 (87.3%) at a mean of 7.3 years postdiagnosis. 302/535 patients (56.4%) had VDI data at LTFU, with 104/302 (34.4%) having ≥5 items and only 24 (7.9%) no items of damage. At 6 months and LTFU, the most frequent items were proteinuria, impaired glomerular filtration rate, hypertension, nasal crusting, hearing loss and peripheral neuropathy. The frequency of damage, including potentially treatment-related damage, rose over time (p<0.01). At LTFU, the most commonly reported items of treatment-related damage were hypertension (41.5%; 95% CI 35.6 to 47.4%), osteoporosis (14.1%; 9.9 to 18.2%), malignancy (12.6%; 8.6 to 16.6%), and diabetes (10.4%; 6.7 to 14.0%).

CONCLUSIONS:

In AAV, renal, otolaryngological and treatment-related (cardiovascular, disease, diabetes, osteoporosis and malignancy) damage increases over time, with around one-third of patients having ≥5 items of damage at a mean of 7 years postdiagnosis.

KEYWORDS:

Disease Activity; Epidemiology; Granulomatosis with polyangiitis; Outcomes research; Treatment

PMID:
24243925
DOI:
10.1136/annrheumdis-2013-203927
[Indexed for MEDLINE]

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