Format

Send to

Choose Destination
See comment in PubMed Commons below
Int J Cancer. 2014 May 15;134(10):2359-65. doi: 10.1002/ijc.28577. Epub 2013 Nov 15.

Meta-analysis of expression of l(3)mbt tumor-associated germline genes supports the model that a soma-to-germline transition is a hallmark of human cancers.

Author information

1
North West Cancer Research Institute, Bangor University, Brambell Building, Bangor, Gwynedd, United Kingdom; Institute for Genomics and Bioinformatics, Graz University of Technology, Graz, Austria.

Abstract

Evidence is starting to emerge indicating that tumorigenesis in metazoans involves a soma-to-germline transition, which may contribute to the acquisition of neoplastic characteristics. Here, we have meta-analyzed gene expression profiles of the human orthologs of Drosophila melanogaster germline genes that are ectopically expressed in l(3)mbt brain tumors using gene expression datasets derived from a large cohort of human tumors. We find these germline genes, some of which drive oncogenesis in D. melanogaster, are similarly ectopically activated in a wide range of human cancers. Some of these genes normally have expression restricted to the germline, making them of particular clinical interest. Importantly, these analyses provide additional support to the emerging model that proposes a soma-to-germline transition is a general hallmark of a wide range of human tumors. This has implications for our understanding of human oncogenesis and the development of new therapeutic and biomarker targets with clinical potential.

KEYWORDS:

cancer; cancer hallmarks; gene expression meta-analysis; meiosis; soma-to-germline transition

PMID:
24243547
PMCID:
PMC4166677
DOI:
10.1002/ijc.28577
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Support Center