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Cell. 2013 Oct 24;155(3):519-29. doi: 10.1016/j.cell.2013.09.044. Epub 2013 Oct 24.

An integrated overview of HIV-1 latency.

Author information

1
Gladstone Institute of Virology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.

Abstract

Despite significant advances in our understanding of HIV, a cure has not been realized for the more than 34 million infected with this virus. HIV is incurable because infected individuals harbor cells where the HIV provirus is integrated into the host's DNA but is not actively replicating and thus is not inhibited by antiviral drugs. Similarly, these latent viruses are not detected by the immune system. In this Review, we discuss HIV-1 latency and the mechanisms that allow this pathogenic retrovirus to hide and persist by exploiting the cellular vehicles of immunological memory.

PMID:
24243012
PMCID:
PMC4361081
DOI:
10.1016/j.cell.2013.09.044
[Indexed for MEDLINE]
Free PMC Article

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