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Cell. 2013 Oct 24;155(3):497-9. doi: 10.1016/j.cell.2013.09.039. Epub 2013 Oct 24.

Stochastic fate selection in HIV-infected patients.

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1
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.

Abstract

Classic studies proposed that stochastic variability ("noise") can drive biological fate switching, enhancing evolutionary success. Now, Ho et al. report that HIV's reactivation from dormant (latently infected) patient cells-the major barrier to an HIV cure-is inherently stochastic. Eradicating an incompletely inducible (probabilistic) viral phenotype will require inventive approaches.

PMID:
24243007
DOI:
10.1016/j.cell.2013.09.039
[Indexed for MEDLINE]
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