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Hum Mol Genet. 2014 Apr 1;23(7):1947-56. doi: 10.1093/hmg/ddt582. Epub 2013 Nov 15.

Sex- and age-interacting eQTLs in human complex diseases.

Author information

1
National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA.

Abstract

Many complex human diseases exhibit sex or age differences in gene expression. However, the presence and the extent of genotype-specific variations in gene regulation are largely unknown. Here, we report results of a comprehensive analysis of expression regulation of genetic variation related to 11,672 complex disease-associated SNPs as a function of sex and age in whole-blood-derived RNA from 5254 individuals. At false discovery rate <0.05, we identified 14 sex- and 10 age-interacting expression quantitative trait loci (eQTLs). We show that these eQTLs are also associated with many sex- or age-associated traits. These findings provide important context regarding the regulation of phenotypes by genotype-environment interaction.

PMID:
24242183
PMCID:
PMC3943525
DOI:
10.1093/hmg/ddt582
[Indexed for MEDLINE]
Free PMC Article

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