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Clin Pharmacol Ther. 2013 Dec;94(6):627-9. doi: 10.1038/clpt.2013.181.

Network medicine in disease analysis and therapeutics.

Author information

1
Division of Systems Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.

Abstract

Two parallel trends are occurring in drug discovery. The first is that we are moving away from a symptom-based disease classification system to a system based on molecules and molecular states. The second is that we are shifting from targeting a single molecule toward targeting multiple molecules, pathways, or networks. Network medicine is an approach to understanding disease and discovering therapeutics looking at many molecules and how they interrelate, and it may play a critical role in the adoption of both trends.

PMID:
24241637
PMCID:
PMC5624966
DOI:
10.1038/clpt.2013.181
[Indexed for MEDLINE]
Free PMC Article

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