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Nat Neurosci. 2014 Jan;17(1):24-6. doi: 10.1038/nn.3583. Epub 2013 Nov 17.

Auto-attraction of neural precursors and their neuronal progeny impairs neuronal migration.

Author information

1
1] Institute of Reconstructive Neurobiology, LIFE and BRAIN Center, University of Bonn and Hertie Foundation, Bonn, Germany. [2].
2
Institute of Reconstructive Neurobiology, LIFE and BRAIN Center, University of Bonn and Hertie Foundation, Bonn, Germany.

Abstract

Limited neuronal migration into host brain tissue is a key challenge in neural transplantation. We found that one important mechanism underlying this phenomenon is an intrinsic chemotactic interaction between the grafted neural precursor cells (NPCs) and their neuronal progeny. NPCs secrete the receptor tyrosine kinase ligands FGF2 and VEGF, which act as chemoattractants for neurons. Interference with these signaling pathways resulted in enhanced migration of human neurons from neural clusters.

PMID:
24241396
DOI:
10.1038/nn.3583
[Indexed for MEDLINE]

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