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Nat Neurosci. 2014 Jan;17(1):30-2. doi: 10.1038/nn.3585. Epub 2013 Nov 17.

Distal connectivity causes summation and division across mouse visual cortex.

Author information

1
UCL Institute of Ophthalmology, University College London, London, UK.
2
Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK.

Abstract

Neurons in different locations across the cortex are connected through polysynaptic networks involving both excitation and inhibition. To probe the functional effect of such networks, we used optogenetic stimulation to trigger antidromic spikes in a local region of primary visual cortex (V1). This local activity had two effects at distal V1 locations: summation and division. The balance between the two depended on visual contrast, and a normalization model precisely captured these effects.

PMID:
24241394
PMCID:
PMC5953407
DOI:
10.1038/nn.3585
[Indexed for MEDLINE]
Free PMC Article

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