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Nat Methods. 2014 Jan;11(1):55-8. doi: 10.1038/nmeth.2730. Epub 2013 Nov 17.

Deciphering laminar-specific neural inputs with line-scanning fMRI.

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1
Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, US National Institutes of Health, Bethesda, Maryland, USA.

Abstract

Using a line-scanning method during functional magnetic resonance imaging (fMRI), we obtained high temporal (50-ms) and spatial (50-μm) resolution information along the cortical thickness and showed that the laminar position of fMRI onset coincides with distinct neural inputs in rat somatosensory and motor cortices. This laminar-specific fMRI onset allowed us to identify the neural inputs underlying ipsilateral fMRI activation in the barrel cortex due to peripheral denervation-induced plasticity.

PMID:
24240320
PMCID:
PMC4276040
DOI:
10.1038/nmeth.2730
[Indexed for MEDLINE]
Free PMC Article
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