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Brain Behav Immun. 2014 Mar;37:109-14. doi: 10.1016/j.bbi.2013.11.006. Epub 2013 Nov 14.

Self-compassion as a predictor of interleukin-6 response to acute psychosocial stress.

Author information

1
Department of Psychology and Volen National Center for Complex Systems, Brandeis University, Waltham, MA, United States. Electronic address: jbreines@brandeis.edu.
2
Department of Psychology and Volen National Center for Complex Systems, Brandeis University, Waltham, MA, United States.

Abstract

We examined the hypothesis that self-compassion is associated with lower levels of stress-induced inflammation. On two consecutive days, plasma concentrations of interleukin-6 (IL-6) were assessed at baseline and at 30 and 120 min following exposure to a standardized laboratory stressor in a sample of 41 healthy young adults. Participants who were higher in self-compassion exhibited significantly lower day 1 IL-6 responses, even when controlling for self-esteem, depressive symptoms, demographic factors, and distress. Self-compassion was not related to day 2 IL-6 response but was inversely related to day 2 baseline IL-6 levels, and to increase in baseline IL-6 from day 1 to day 2. These findings suggest that self-compassion may serve as a protective factor against stress-induced inflammation and inflammation-related disease.

KEYWORDS:

Acute psychosocial stress; Inflammation; Interleukin-6; Self-compassion; Self-esteem

PMID:
24239953
PMCID:
PMC4311753
DOI:
10.1016/j.bbi.2013.11.006
[Indexed for MEDLINE]
Free PMC Article

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