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Am J Ophthalmol. 2014 Mar;157(3):540-9.e1-2. doi: 10.1016/j.ajo.2013.11.007. Epub 2013 Nov 13.

A method to estimate the amount of neuroretinal rim tissue in glaucoma: comparison with current methods for measuring rim area.

Author information

1
Devers Eye Institute, Legacy Research Institute, Portland, Oregon. Electronic address: sgardiner@deverseye.org.
2
Devers Eye Institute, Legacy Research Institute, Portland, Oregon; New York Eye and Ear Infirmary, New York, New York.
3
Devers Eye Institute, Legacy Research Institute, Portland, Oregon.

Abstract

PURPOSE:

To test whether the minimum rim area assessed by spectral domain optical coherence tomography (SD-OCT), based on the shortest distance from the Bruch membrane opening (BMO) to the inner limiting membrane, corresponds more closely to retinal nerve fiber layer (RNFL) thickness and visual field mean deviation (MD) than current rim measures in early glaucoma.

DESIGN:

Prospective cross-sectional study.

METHODS:

We studied 221 participants with non-endstage glaucoma or high-risk ocular hypertension and performed standard automated perimetry. We received SD-OCT and confocal scanning laser ophthalmoscopy (CSLO) scans on the same day. Rim area measured by CSLO was compared with 3 SD-OCT rim measures from radial B-scans: horizontal rim area between BMO and inner limiting membrane within the BMO plane; mean minimum rim width (BMO-MRW); and minimum rim area (BMO-MRA) optimized within sectors and then summed. Correlations between these measures and either MD from perimetry or RNFL thickness from SD-OCT were compared using the Steiger test.

RESULTS:

RNFL thickness was better correlated with BMO-MRA (r = 0.676) or BMO-MRW (r = 0.680) than with either CSLO rim area (r = 0.330, P < 0.001) or horizontal rim area (r = 0.482, P < 0.001). MD was better correlated with BMO-MRA (r = 0.534) or BMO-MRW (r = 0.546) than with either CSLO rim area (r = 0.321, P < 0.001) or horizontal rim area (0.403, P < 0.001). The correlation between MD and RNFL thickness was r = 0.646.

CONCLUSIONS:

Minimum rim measurements from SD-OCT are significantly better correlated to both RNFL thickness and MD than rim measurements within the BMO plane or based on the clinical disc margin. They provide new structural parameters for both diagnostic and research purposes in glaucoma.

PMID:
24239775
PMCID:
PMC3944716
DOI:
10.1016/j.ajo.2013.11.007
[Indexed for MEDLINE]
Free PMC Article

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