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Drug Discov Today. 2014 May;19(5):637-44. doi: 10.1016/j.drudis.2013.11.005. Epub 2013 Nov 14.

Toward better drug repositioning: prioritizing and integrating existing methods into efficient pipelines.

Author information

1
Department of Systems Medicine and Bioengineering, Houston Methodist Research Institute, Weill Cornell Medical College, Houston, TX 77030, USA; NCI Center for Modeling Cancer Development, Houston Methodist Research Institute, Houston, TX 77030, USA.
2
Department of Systems Medicine and Bioengineering, Houston Methodist Research Institute, Weill Cornell Medical College, Houston, TX 77030, USA; NCI Center for Modeling Cancer Development, Houston Methodist Research Institute, Houston, TX 77030, USA. Electronic address: stwong@tmhs.org.

Abstract

Recycling old drugs, rescuing shelved drugs and extending patents' lives make drug repositioning an attractive form of drug discovery. Drug repositioning accounts for approximately 30% of the newly US Food and Drug Administration (FDA)-approved drugs and vaccines in recent years. The prevalence of drug-repositioning studies has resulted in a variety of innovative computational methods for the identification of new opportunities for the use of old drugs. Questions often arise from customizing or optimizing these methods into efficient drug-repositioning pipelines for alternative applications. It requires a comprehensive understanding of the available methods gained by evaluating both biological and pharmaceutical knowledge and the elucidated mechanism-of-action of drugs. Here, we provide guidance for prioritizing and integrating drug-repositioning methods for specific drug-repositioning pipelines.

PMID:
24239728
PMCID:
PMC4021005
DOI:
10.1016/j.drudis.2013.11.005
[Indexed for MEDLINE]
Free PMC Article
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