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Magn Reson Imaging. 2014 Jan;32(1):84-90. doi: 10.1016/j.mri.2013.04.006. Epub 2013 Nov 12.

Quantifying liver fibrosis through the application of texture analysis to diffusion weighted imaging.

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Boston University Medical Center, Department of Radiology, FGH Building, 3rd Floor, 820 Harrison Avenue, Boston, MA 02218, USA.


The purpose of this study was to evaluate the potential utility of texture analysis of parametric apparent diffusion coefficient (ADC) maps in quantifying hepatic fibrosis. To this end, using ex vivo murine liver tissues from a dietary model of hepatic fibrosis, an array of texture analysis techniques, including histogram-based, gray-level co-occurrence matrix-based, and gray-level run-length-based features, was used to evaluate correlations with liver fibrosis. Moderate to very strong correlation between several of the texture-based features and both subjective as well as digital image analysis-based assessments of hepatic fibrosis was demonstrated. This rigorous study of texture analysis applied to parametric ADC maps in a liver fibrosis model study demonstrates and validates the potential utility of texture-based features for the noninvasive, quantitative assessment of hepatic fibrosis.


Diffusion; Fibrosis; Liver; Mouse; Texture

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