Format

Send to

Choose Destination
Trends Pharmacol Sci. 2013 Dec;34(12):648-55. doi: 10.1016/j.tips.2013.10.005. Epub 2013 Nov 12.

AKAP signaling complexes: pointing towards the next generation of therapeutic targets?

Author information

1
Howard Hughes Medical Institute, Department of Pharmacology, University of Washington School of Medicine, Seattle, WA, USA.

Abstract

A-kinase anchoring proteins (AKAPs) streamline signal transduction by localizing signaling enzymes with their substrates. Great strides have been made in elucidating the role of these macromolecular signaling complexes as new binding partners and novel AKAPs are continually being uncovered. The mechanics and dynamics of these multi-enzyme assemblies suggest that AKAP complexes are viable targets for therapeutic intervention. This review will highlight recent advances in AKAP research focusing on local signaling events that are perturbed in disease.

KEYWORDS:

AKAP; Ca(2+); disease; interfering peptide; protein kinase; protein phosphatase; signal transduction

PMID:
24239028
PMCID:
PMC3879114
DOI:
10.1016/j.tips.2013.10.005
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center