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Trends Cogn Sci. 2013 Dec;17(12):666-82. doi: 10.1016/j.tics.2013.09.016. Epub 2013 Nov 12.

Functional connectomics from resting-state fMRI.

Author information

1
Oxford Centre for Functional MRI of the Brain (FMRIB), University of Oxford, Oxford, UK. Electronic address: steve@fmrib.ox.ac.uk.

Abstract

Spontaneous fluctuations in activity in different parts of the brain can be used to study functional brain networks. We review the use of resting-state functional MRI (rfMRI) for the purpose of mapping the macroscopic functional connectome. After describing MRI acquisition and image-processing methods commonly used to generate data in a form amenable to connectomics network analysis, we discuss different approaches for estimating network structure from that data. Finally, we describe new possibilities resulting from the high-quality rfMRI data being generated by the Human Connectome Project and highlight some upcoming challenges in functional connectomics.

KEYWORDS:

connectomics; network modelling; resting-state fMRI

PMID:
24238796
PMCID:
PMC4004765
DOI:
10.1016/j.tics.2013.09.016
[Indexed for MEDLINE]
Free PMC Article
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