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Trends Plant Sci. 2014 Feb;19(2):123-32. doi: 10.1016/j.tplants.2013.10.003. Epub 2013 Nov 12.

Two for all: receptor-associated kinases SOBIR1 and BAK1.

Author information

1
Laboratory of Phytopathology, Wageningen University, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands; Centre for BioSystems Genomics, Droevendaalsesteeg 1, 6700 AB Wageningen, The Netherlands.
2
Molecular Plant Pathology, Swammerdam Institute for Life Sciences (SILS), University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands.
3
Laboratory of Phytopathology, Wageningen University, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands; Centre for BioSystems Genomics, Droevendaalsesteeg 1, 6700 AB Wageningen, The Netherlands. Electronic address: Matthieu.Joosten@wur.nl.

Abstract

Leucine-rich repeat-receptor-like proteins (LRR-RLPs) are ubiquitous cell surface receptors lacking a cytoplasmic signalling domain. For most of these LRR-RLPs, it remained enigmatic how they activate cellular responses upon ligand perception. Recently, the LRR-receptor-like kinase (LRR-RLK) SUPPRESSOR OF BIR1-1 (SOBIR1) was shown to be essential for triggering defence responses by certain LRR-RLPs that act as immune receptors. In addition to SOBIR1, the regulatory LRR-RLK BRI1-ASSOCIATED KINASE-1 (BAK1) is also required for LRR-RLP function. Here, we compare the roles of SOBIR1 and BAK1 as regulatory LRR-RLKs in immunity and development. BAK1 has a general regulatory role in plasma membrane-associated receptor complexes comprising LRR-RLPs and/or LRR-RLKs. By contrast, SOBIR1 appears to be specifically required for the function of receptor complexes containing LRR-RLPs.

KEYWORDS:

development; genome collinearity; innate immunity; receptor-like protein; regulatory receptor-like kinase

PMID:
24238702
DOI:
10.1016/j.tplants.2013.10.003
[Indexed for MEDLINE]

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