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Gastrointest Endosc. 2014 May;79(5):750-5. doi: 10.1016/j.gie.2013.09.028. Epub 2013 Nov 12.

Suck-ligate-unroof-biopsy by using a detachable 20-mm loop for the diagnosis and therapy of small subepithelial tumors (with video).

Author information

1
Paul May & Frank Stein Interventional Endoscopy Center, California Pacific Medical Center, San Francisco, California, USA.

Erratum in

  • Gastrointest Endosc. 2014 Jul;80(1):196.

Abstract

BACKGROUND:

The diagnosis and therapy of subepithelial tumors (SETs) can be challenging.

OBJECTIVE:

Proof-of-concept evaluation of the suck-ligate-unroof-biopsy (SLUB) technique for small (<2 cm), non-pedunculated SETs.

DESIGN:

Pilot feasibility study.

SETTING:

Tertiary-care referral center.

PATIENTS:

Twenty-three patients (median age 60 years) meeting the inclusion criteria after preliminary EUS.

INTERVENTION:

SET ligation was performed with a detachable 20-mm loop deployed through an 18-mm diameter, soft, oblique, transparent, cap attachment. The SLUB technique comprised (1) suction to draw the SET into the cap; (2) ligation below the SET, confirmation by repeat EUS; (3) unroofing of the overlying mucosa with a needle-knife; and (4) biopsy specimens taken from the exposed tumor.

MAIN OUTCOME MEASUREMENTS:

Technical success, histology and/or immunohistochemistry yield, adverse events, completeness of resection.

RESULTS:

SLUB was attempted on 24 SETs and was technically successful in all. Location was the stomach (n = 19), small bowel (n = 1), colon (n = 2), and rectum (n = 2). Median size by EUS was 10 mm (range 6-15 mm). Biopsy specimens provided an immunohistologic diagnosis in all cases: GI stromal tumor (n = 5), leiomyoma (n = 8), carcinoid tumor (n = 5), Vanek's tumor (n = 2), granuloma (n =1), and pancreatic heterotopia (n = 3). Follow-up endoscopy and EUS in 13 patients showed well-healed scars with no residual tumor, including all 9 patients with premalignant neoplastic lesions. The only adverse event was self-limited pain in 2 patients.

LIMITATIONS:

Single center, single operator, small sample size.

CONCLUSIONS:

Loop ligation of small, non-pedunculated SETs is feasible by using a cap attachment for suction. Unroofing after ligation is safe and provides sufficient tissue for immunohistochemistry. Ligation combined with unroofing appears to lead to complete ablation by ischemia and tumor enucleation.

PMID:
24238309
DOI:
10.1016/j.gie.2013.09.028
[Indexed for MEDLINE]
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