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Diabet Med. 2014 May;31(5):559-63. doi: 10.1111/dme.12360. Epub 2013 Dec 6.

Increased intestinal permeability to oral chromium (51 Cr) -EDTA in human Type 2 diabetes.

Author information

1
Department of Nuclear Medicine, Royal Surrey County Hospital, Guildford, UK.

Abstract

OBJECTIVE:

In animal models of obesity and Type 2 diabetes, permeability of the intestine is increased because of impairment of tight junction proteins, allowing translocation of bacterial endotoxin and resulting in low-grade systemic inflammation. This has yet to be demonstrated in humans. The objective of this study was the demonstration of increased intestinal permeability in human Type 2 diabetes.

METHODS:

We examined intestinal permeability using chromium ((51) Cr)-EDTA urinary recovery in twenty well-controlled men with Type 2 diabetes compared with control subjects matched for age, gender and BMI.

RESULTS:

Intestinal permeability was significantly increased (P = 0.002) in the diabetic group and was correlated to increased levels of systemic inflammatory markers high-sensitivity C-reactive protein (r = 0.694, P = 0.001), interleukin 6 (r = 0.548, P = 0.012) and tumour necrosis factor alpha (r = 0.564, P = 0.010).

CONCLUSION:

This is the first demonstration that increased intestinal permeability may be a feature of human Type 2 diabetes.

PMID:
24236770
DOI:
10.1111/dme.12360
[Indexed for MEDLINE]

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