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J Comp Eff Res. 2013 Jul;2(4):383-91. doi: 10.2217/cer.13.39.

When is evidence sufficient for decision-making? A framework for understanding the pace of evidence adoption.

Author information

1
National Pharmaceutical Council, 1717 Pennsylvania Avenue, NW, Suite 800, Washington, DC 20006, USA. rdubois@npcnow.org.

Abstract

Translation of medical evidence into practice has not kept pace with the growth of medical technology and knowledge. We present three case studies--statins, drug eluting stents and bone marrow transplantation for breast cancer--to propose a framework for describing five factors that may influence the rate of adoption. The factors are: validity, reliability and maturity of the science available before widespread adoption; communication of the science; economic drivers; patients' and physicians' ability to apply published scientific findings to their specific clinical needs; and incorporation into practice guidelines.

PMID:
24236680
DOI:
10.2217/cer.13.39
[Indexed for MEDLINE]
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