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In Vitro Cell Dev Biol. 1986 May;22(5):280-4.

Conditions affecting the differentiation of F9 teratocarcinoma cells: potentiation of response by cyclic AMP.

Abstract

F9 cells maintained in culture were shown to have a reduced ability to differentiate. The cells produced decreased amounts of alphafetoprotein when induced with retinoic acid. We show that consistent responses can be recovered after passage of F9 cells as a tumor. In addition, optimal differentiation of F9 cells to visceral endoderm may be achieved by the addition of very low concentrations of dibutyryl cyclic AMP (dbcAMP) to the medium.

PMID:
2423499
DOI:
10.1007/bf02621231
[Indexed for MEDLINE]

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