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Life Sci. 2014 Feb 27;97(1):20-6. doi: 10.1016/j.lfs.2013.10.029. Epub 2013 Nov 11.

Synthetic cathinones: chemical phylogeny, physiology, and neuropharmacology.

Author information

1
Department of Physiology and Biophysics, School of Medicine, USA. Electronic address: ljdefelice@vcu.edu.
2
Department of Medicinal Chemistry, School of Pharmacy, USA.
3
Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.

Abstract

This mini-review summarizes the history of cathinone and its synthesized derivatives from early records to the present day, including the appearance of synthetic cathinones in the drug combination known as bath salts. Bath salts may consist of one compound (MDPV) or combinations of MDPV and one or more other synthetic cathinones, which may also appear alone without MDPV. We briefly review recent in vitro studies of bath salts components alone or in combination, focusing on pharmacological and biophysical studies. Finally we summarize new data from in vivo procedures that characterize the abuse-related neurochemical and behavioral effects of synthetic cathinones in rats.

KEYWORDS:

Amphetamine; Bath salts; Cocaine; Dopamine; Intracranial selfstimulation (ICSS); MDPV; Mephedrone; Methamphamine; Methcathinone; Methylone; Serotonin; Synthetic cathinones; Transporters

PMID:
24231923
PMCID:
PMC3944897
DOI:
10.1016/j.lfs.2013.10.029
[Indexed for MEDLINE]
Free PMC Article

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