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Arch Phys Med Rehabil. 2014 May;95(5):996-9. doi: 10.1016/j.apmr.2013.10.020. Epub 2013 Nov 11.

Impact of physical exercise on reaction time in patients with Parkinson's disease-data from the Berlin BIG Study.

Author information

1
Movement Disorders Hospital, Beelitz-Heilstätten, Germany. Electronic address: ebersbach@parkinson-beelitz.de.
2
Movement Disorders Hospital, Beelitz-Heilstätten, Germany.
3
Institute of Medical Biometrics and Clinical Epidemiology, Charité University Medicine Berlin, Berlin, Germany.
4
Vivantes-Klinikum Spandau, Berlin, Germany.
5
Department of Neurology and Stereotactic Neurosurgery, Otto-von-Guericke-University, Magdeburg, Germany.

Abstract

OBJECTIVE:

To determine whether physical activity may affect cognitive performance in patients with Parkinson's disease by measuring reaction times in patients participating in the Berlin BIG study.

DESIGN:

Randomized controlled trial, rater-blinded.

SETTING:

Ambulatory care.

PARTICIPANTS:

Patients with mild to moderate Parkinson's disease (N=60) were randomly allocated to 3 treatment arms. Outcome was measured at the termination of training and at follow-up 16 weeks after baseline in 58 patients (completers).

INTERVENTIONS:

Patients received 16 hours of individual Lee Silverman Voice Treatment-BIG training (BIG; duration of treatment, 4wk), 16 hours of group training with Nordic Walking (WALK; duration of treatment, 8wk), or nonsupervised domestic exercise (HOME; duration of instruction, 1hr).

MAIN OUTCOME MEASURES:

Cued reaction time (cRT) and noncued reaction time (nRT).

RESULTS:

Differences between treatment groups in improvement in reaction times from baseline to intermediate and baseline to follow-up assessments were observed for cRT but not for nRT. Pairwise t test comparisons revealed differences in change in cRT at both measurements between BIG and HOME groups (intermediate: -52ms; 95% confidence interval [CI], -84/-20; P=.002; follow-up: 55ms; CI, -105/-6; P=.030) and between WALK and HOME groups (intermediate: -61ms; CI, -120/-2; P=.042; follow-up: -78ms; CI, -136/-20; P=.010). There was no difference between BIG and WALK groups (intermediate: 9ms; CI, -49/67; P=.742; follow-up: 23ms; CI, -27/72; P=.361).

CONCLUSION:

Supervised physical exercise with Lee Silverman Voice Treatment-BIG or Nordic Walking is associated with improvement in cognitive aspects of movement preparation.

KEYWORDS:

Exercise; Parkinson's disease; Reaction times; Rehabilitation

PMID:
24231400
DOI:
10.1016/j.apmr.2013.10.020
[Indexed for MEDLINE]

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