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Cancer Cell. 2013 Nov 11;24(5):557-9. doi: 10.1016/j.ccr.2013.10.016.

Sox4you: a new player in C/EBPα leukemia.

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1
Leukaemia and Stem Cell Biology Section, Division of Cancer Studies, Department of Haematological Medicine, King's College London, London SE5 9NU, UK.

Abstract

Although CEBPA mutations are among the most common genetic abnormalities in acute myeloid leukemia (AML), the transformation mechanism remains largely obscure. In this issue of Cancer Cell, Zhang and colleagues report that SOX4 is a direct target and crucial mediator of C/EBPα mutants in AML, revealing a potential therapeutic avenue.

PMID:
24229703
DOI:
10.1016/j.ccr.2013.10.016
[Indexed for MEDLINE]
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