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BMC Biol. 2013 Sep 30;11:102. doi: 10.1186/1741-7007-11-102.

Deciphering the role of natural variation in age-related protein homeostasis.

Author information

  • 1Department of Pathology, University of Washington, 1959 NE Pacific Street, D-514, Seattle, WA 98195-7470, USA. kaeber@uw.edu.

Abstract

Understanding the genetic basis of age-related diseases is a critical step toward developing therapies that promote healthy aging. Numerous genes have been identified that modulate lifespan, but the influence of natural variation in aging has not been well studied. A new report utilizing a transgenic protein aggregation model in Caenorhabditis elegans has provided important tools and insights into the relationship between natural genetic variation, protein aggregation, and age-related pathology.See research article: http://www.biomedcentral.com/1741-7007/11/100.

PMID:
24228595
PMCID:
PMC3849513
DOI:
10.1186/1741-7007-11-102
[PubMed - indexed for MEDLINE]
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