Send to

Choose Destination
Korean J Physiol Pharmacol. 2013 Oct;17(5):423-6. doi: 10.4196/kjpp.2013.17.5.423. Epub 2013 Oct 17.

Estrogen rather than progesterone cause constipation in both female and male mice.

Author information

Obesity-Diabetes Advanced Research Center, School of Medicine, Yeungnam University, Daegu 705-717, Korea.


Females are more often affected by constipation than males, especially during pregnancy, which is related to the menstrual cycle. Although still controversial, alterations of progesterone and estrogen may be responsible. Therefore, this study was conducted in order to determine whether the female sex steroid hormone itself is responsible for development of constipation in both female and male mice. Administration of estrogen resulted in a decrease in weight of accumulated feces on days 2, 3, 4, and 5 in male mice and on day 5 in female mice, compared with the control group, but progesterone administration did not. Administration of estrogen resulted in a decrease in gastrointestinal movement, compared to normal; however, no significant change was observed by administration of progesterone. In conclusion, estrogen, rather than progesterone, may be a detrimental factor of constipation via decreased bowel movement in mice.


Constipation; Estrogen; Progesterone

Supplemental Content

Full text links

Icon for The Korean Physiological Society and The Korean Society of Pharmacology Icon for PubMed Central
Loading ...
Support Center